Welcome to CAGI project!
The Critical Assessment of Genome Interpretation (CAGI, \'kā-jē\) is a community experiment to objectively assess computational methods for predicting the phenotypic impacts of genomic variation. In this experiment, modeled on the Critical Assessment of Structure Prediction (CASP), participants will be provided genetic variants and will make predictions of resulting molecular, cellular, or organismal phenotype. These predictions will be evaluated against experimental characterizations, and independent assessors will perform the evaluations. Community workshops will be held to disseminate results, assess our collective ability to make accurate and meaningful phenotypic predictions, and better understand progress in the field. From this experiment, we expect to identify bottlenecks in genome interpretation, inform critical areas of future research, and connect researchers from diverse disciplines whose expertise is essential to methods for genome interpretation.
The submission deadlines for CAGI 2011 experiment have passed for all challenges. However, we welcome the upload of predictions after the deadline for archival and comparison purposes, but these post-deadline submissions are not part of the CAGI experiment.
The assessment season is now ongoing, and preliminary assessments are available for registered users.
The CAGI 2011 Conference took place in 9 - 10 December 2011. The conference presentations are available for registered users.
Experimental results for the following CAGI 2011 challenges have been published:
CAGI 2010
The first round of CAGI was organized in the fall 2010. We want to express our appreciation to everyone who participated in CAGI and RiskSNPs 2010. This initial experiment was a great success with over 100 prediction submissions from 8 countries. The workshop on 10 December 2010 gathered an enthusiastic international group of 40 people at Berkeley. We are completing prediction assessments from CAGI 2010 for publication. A summary of the proceedings was published in
Nature News. We want to emphasize that CAGI is a community experiment to understand and improve the interpretation of genome variation. It is not a contest and all predictors were awarded recognition for their participation in the meeting.
Results and presentations discussing CAGI 2010 are available on the CAGI 2010 Results page.